The Korea Football Association [KFA] have said Son will miss their World Cup qualifier against Lebanon on Tuesday and the 29-year-old will now return to Spurs to be assessed.
Son played the full 90 minutes for South Korea in their 0-0 draw with Iraq on Thursday but the KFA say he has an issue with his right calf muscle.
The injury is a concern for Tottenham ahead of an important run of games this month.
Son is a doubt for Saturday’s lunchtime kick-off against Crystal Palace at Selhurst Park and Spurs also have London derbies coming up against rivals Chelsea on September 19 and then Arsenal on September 26.
Son has been in good form at the start of the season and scored the winner for Tottenham in their 1-0 victory against Manchester City on the opening day of the season and then against Watford before the international break.
Tottenham travel to Selhurst Park this weekend sitting top of the Premier League after three wins from their first three matches under new head coach Nuno Espirito Santo.